解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The genotoxicity of 2-nitropropane (2-NP) and 1-nitropropane (1-NP) was investigated by measuring the induction of DNA repair synthesis in rat liver cells in vitro and in vivo. 2-NP strongly induced DNA repair synthesis in both cases. When applied in vivo, 2-NP was considerably more effective in hepatocytes from males...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.5.811
更新日期:1988-05-01 00:00:00
abstract::Azido-IQ (2-azido-3-methylimidazo[4,5-f]quinoline), a novel analog of the food mutagen and carcinogen IQ (2-amino-3-methylimidazo[4,5-f]quinoline) was synthesized and characterized. Both thermolysis and photolysis of this azide yield a short-lived nitrene which can react as an electrophile either directly or via proto...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.5.869
更新日期:1988-05-01 00:00:00
abstract::The HBL100 cell line, established in vitro from milk of an apparently healthy woman, expresses SV40 large T antigen defective in some of its functions. Here we demonstrate that the HBL100 genomic DNA possesses transforming activity in NIH3T3 cells and that this activity is associated with the viral information. ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.4.653
更新日期:1988-04-01 00:00:00
abstract::Glucosinolates are common components of cruciferous vegetables that can be hydrolyzed during food processing to yield isothiocyanates, some of which have been shown to inhibit the induction of mammary tumors in rats by 7,12-dimethyl-benz[a]anthracene. To determine how intact glucosinolates affect the metabolism of ben...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.4.657
更新日期:1988-04-01 00:00:00
abstract::Previous results in a number of laboratories have demonstrated that epidermal papillomas and carcinomas induced by the two-stage protocol of initiation and promotion contain a point mutation in the 61st codon of the c-Ha-ras oncogene when the initiating agent used is 7,12-dimethylbenz[a]anthracene (DMBA). In the prese...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.4.665
更新日期:1988-04-01 00:00:00
abstract::The expression of A and P forms of glutathione S-transferase (GST-A and P), two cytochrome P-450 isoenzymes (P-450 PB3a and P-450 MC2), microsomal epoxide hydrolase (mEHb), glucose-6-phosphate dehydrogenase (G6PD) and gamma-glutamyltranspeptidase (gamma-GT) was compared in preneoplastic liver lesions and background pa...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.4.547
更新日期:1988-04-01 00:00:00
abstract::Optimal proliferation of cultured hepatocytes from normal rats occurs in response to epidermal growth factor (EGF) at an extracellular calcium concentration of 0.4 mM, whereas physiological concentrations of calcium have been shown to decrease hepatocyte proliferation. Exposure of hepatocytes in vivo to phenobarbital ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.3.479
更新日期:1988-03-01 00:00:00
abstract::A large series of assays of the hepatocarcinogenic potential of 112 different compounds were carried out using a rapid bioassay system developed in this laboratory based on the two-step concept of hepatocarcinogenesis. Rats were initially given a single dose (200 mg/kg) of diethylnitrosamine (DEN) i.p. and starting 2 ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.3.387
更新日期:1988-03-01 00:00:00
abstract::In a previous study a high first-pass metabolism of N-nitrosodi-[1-14C]amylamine (NDAA, 0.59-350 microM) has been shown in isolated perfused rat small intestinal segments. In the present work the identification of metabolites in samples of perfusate and absorbed fluid (absorbate) is reported. After HPLC enrichment and...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.3.507
更新日期:1988-03-01 00:00:00
abstract::Both trans-4-acetylaminostilbene (AAS) and 2-acetylaminofluorene (AAF) exert tumor-initiating activity in rat liver when administered in the initiation phase of an initiation-promotion experiment. The effects are more than additive when the compounds are sequentially combined in the initiation phase of such an experim...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.2.265
更新日期:1988-02-01 00:00:00
abstract::A family of 2-amino-N-methylimidazoazaarene (AIA) mutagens are produced in meats by cooking, and are of concern as potential carcinogens in the human diet. These are potent genotoxins in bacterial mutation assays, but are present only in trace quantities in cooked foods. Conventional analytical chemistry methods have ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.1.153
更新日期:1988-01-01 00:00:00
abstract::Carcinogenicity of 2-amino-3,8-dimethylimidazo[4,5-f]-quinoxaline (MeIQx), which is a potent mutagen first isolated from fried beef and widely present in various cooked foods, was tested in both sexes of F344 rats. Rats were continuously given a diet containing 0.04% MeIQx or basal diet and the experiment was finished...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/9.1.71
更新日期:1988-01-01 00:00:00
abstract::The metabolism of [1,3-14C]benzo[f]quinoline (BfQ) by liver microsomes from control, 3-methylcholanthrene (3-MC)-pretreated and phenobarbital (PB)-pretreated rats has been investigated in order to gain insights into the effect of mixed function oxidase inducers on the types and levels of specific metabolites as formed...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.12.1861
更新日期:1987-12-01 00:00:00
abstract::The effects of exposure to benzo[a]pyrene (BAP) and formaldehyde (HCHO), alone and combined, on the induction of carcinogenesis in rat tracheal implants was determined as the number of growth-altered cell populations (tumor-initiation sites, TIS) per trachea. While exposure twice-weekly for 4.5 months to 0.2% HCHO sol...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.12.1951
更新日期:1987-12-01 00:00:00
abstract::The metabolism in mouse epidermis of benzo[b]fluoranthene (BbF) was studied. [3H]BbF was applied topically, mice were killed at various intervals, and metabolites were extracted from the epidermis and analyzed by h.p.l.c. The major metabolites were identified by comparisons to standards as 4-, 5-, and 6-hydroxyBbF. Su...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.11.1579
更新日期:1987-11-01 00:00:00
abstract::In the present study the role of two families of cytochrome P-450 proteins and the contribution of the cytosolic fraction in the activation of N-nitrosopiperidine to mutagens in the Ames test were investigated. The bioactivation of this nitrosamine was preferentially catalysed by the phenobarbitone-induced cytochromes...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.11.1691
更新日期:1987-11-01 00:00:00
abstract::Chemical carcinogenesis in mouse skin has been divided into the process of initiation, promotion and progression. Recently we have shown that ionizing radiation acts as an initiator in this model system. In this paper we describe a three-stage experiment using ionizing radiation in the third stage of mouse skin carcin...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.11.1753
更新日期:1987-11-01 00:00:00
abstract::Previous epidemiological and laboratory studies have indicated an association between the ingestion of opium pyrolysates, dietary deficiencies and the high incidence of oesophageal cancer in subjects in north-east Iran. Pyrolysates of opium, and particularly of morphine, a major opium alkaloid, were both shown to cont...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.10.1423
更新日期:1987-10-01 00:00:00
abstract::Yeasts were isolated from 12 cases of oral precancerous lesions (leukoplakia and erythroleukoplakia) by sampling the lesion as well as normal mucosa of each patient, yielding 21 strains of Candida albicans belonging to 15 biotypes, two strains of C. tropicalis, one strain of C. parapsilosis and two strains of Torulops...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.10.1543
更新日期:1987-10-01 00:00:00
abstract::Male F344 rats were administered phenobarbital, polychlorinated biphenyl (PCB), retinol acetate, indomethacin, 6-amino-caproic acid, dexamethasone (DEX) or diethylmaleate (DEM) for one week and then were treated with these chemicals plus butylated hydroxyanisole (BHA) for a further four weeks. Histopathologically, the...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.10.1555
更新日期:1987-10-01 00:00:00
abstract::The purpose of this work was to study the relative activities and stabilities of phase-I and phase-II drug metabolizing enzymes in incubation mixtures used in vitro genotoxicity testing in order to optimize the conditions of the assay, increase sensitivity and eliminate false negative results. Cytochrome P-450, NADPH-...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.9.1179
更新日期:1987-09-01 00:00:00
abstract::This study was undertaken to investigate the hypothesis linking peroxisome proliferation with the production of reactive oxygen species and subsequent DNA damage. Hepatic peroxisomal proliferation was induced in male Wistar-derived rats by the administration of clofibrate, methyl clofenapate, di(2-ethylhexyl)phthalate...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.9.1213
更新日期:1987-09-01 00:00:00
abstract::We have previously demonstrated that the active dihydrofolate reductase (DHFR) gene is efficiently repaired in Chinese hamster ovary (CHO) cells which remove only a small fraction of u.v.-induced pyrimidine dimers from the overall genome. Preferential DNA repair of essential genes may explain why the u.v. resistance o...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.9.1333
更新日期:1987-09-01 00:00:00
abstract::The effect of phenobarbital (PB), p,p'-dichlorodiphenyltrichloroethane (DDT) or carbon tetrachloride (CCl4) on dimethylnitrosamine (DMN)-induced hepatocarcinogenesis in Syrian golden hamsters was examined. Hamsters were given a single injection of DMN (6 mg/kg body wt) followed by either PB or DDT in the diet or repea...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.9.1171
更新日期:1987-09-01 00:00:00
abstract::The metabolism of N-nitrosobis(2-oxopropyl)amine (BOP) was examined in microsomes from uninduced F-344 rats. Even when the conditions were varied, no metabolism of this compound was detected. On the other hand, freshly isolated hepatocytes from F-344 rats metabolized BOP efficiently to CO2. The kinetics of conversion ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.8.1095
更新日期:1987-08-01 00:00:00
abstract::The purpose of this study was to compare the metabolism and DNA binding of aflatoxicol (AFL) with that of aflatoxin B1 (AFB1) in vivo and in isolated hepatocytes from Mt Shasta strain rainbow trout (Salmo gairdneri). Maximum total binding of [3H]AFL to liver DNA from trout exposed by intraperitoneal injection was 38-4...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.8.1065
更新日期:1987-08-01 00:00:00
abstract::The survival of transfected simian virus (SV) 40 DNA is acutely sensitive to damage in a 302-bp regulatory region that governs viral gene expression and the initiation of viral DNA replication. We investigated whether the lethal effect of damage in this region is due to the disruption of gene expression or to the inhi...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.8.1133
更新日期:1987-08-01 00:00:00
abstract::The effect of the aromatic amines 2-acetylaminofluorene (AAF), 2-acetylaminophenanthrene (AAP) and trans-4-acetylaminostilbene (AAS) on the rat hepatic aromatic hydrocarbon (Ah) receptor level was studied. 3-Methylcholanthrene (MC), as a known receptor ligand, was used as a control. The complete liver carcinogen AAF a...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.7.1021
更新日期:1987-07-01 00:00:00
abstract::The ability of three benzodiazepine tranquilizers, diazepam, oxazepam and chlordiazepoxide chlorhydrate to block metabolic cooperation between human hepatoma cells was analysed using autoradiographical monitoring. Independent tests were performed with compound concentrations varying from 1 to 50 micrograms/ml. The res...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.7.1013
更新日期:1987-07-01 00:00:00
abstract::Nutritional deficiencies or imbalances are suspected contributory factors to several types of human cancers, and perhaps other human diseases related to long-term metabolic derangements. In order to study these more effectively in laboratory animals, it is suggested that the laboratory diets more closely mimic the nut...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.7.871
更新日期:1987-07-01 00:00:00
abstract::Cultures of isolated human hepatocytes from three different human liver specimens were exposed for 24 h to media containing [3H]benzo[a]pyrene (BP) (0.1, 1.0, 10, 100 microM). The cells and media were harvested and extracted. Subsequent incubations of the aqueous phase with beta-glucuronidase and aryl sulfatase, follo...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.7.983
更新日期:1987-07-01 00:00:00
abstract::Semi-permeable magnetic polyethyleneimine (PEI) microcapsules have been developed to trap carcinogens and their metabolites in vivo and their time-dependent binding of a model carcinogen, [14C]benzo[a]pyrene [( 14C]BaP), is studied within the intestinal lumen. Overall, approximately 0.5% of an intragastric BaP dose wa...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.6.825
更新日期:1987-06-01 00:00:00
abstract::The modifying effects of 4,4'-diaminodiphenylmethane (DDPM) (0.1% in diet) administration on liver carcinogenesis induced by 2-acetylaminofluorene (2-AAF) (0.02% in diet), 3'-methyl-4-dimethylaminoazobenzene (3'-Me-DAB) ( 0.06% in diet), diethylnitrosamine (DEN) (0.001% in drinking water) and N-ethyl-N-hydroxyethylnit...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.5.719
更新日期:1987-05-01 00:00:00
abstract::Pretreatment of Fischer 344 rats with the antioxidant ethoxyquin (EQ), followed by administration of aflatoxin B1 (AFB1) in the continuing presence of EQ was used to examine the effect of the antioxidant on liver and kidney. EQ (0.5% in diet) completely prevented the formation of AFB1-induced preneoplastic liver lesio...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.5.723
更新日期:1987-05-01 00:00:00
abstract::3-Amino-1,2,4-triazole, a thyroid carcinogen and goitrogen, is negative in a wide variety of short-term mutagenicity assays. However, amitrole induces gene mutations and morphological transformation in Syrian hamster embryo fibroblasts, cells known to carry out the prostaglandin H synthase (PHS)-mediated peroxidative ...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.5.659
更新日期:1987-05-01 00:00:00
abstract::The effect of daily parenteral administration of a long-acting analogue of somatostatin (SMS 201-995) on the development of intestinal tumours and the rate of crypt cell proliferation in azoxymethane-treated rats has been studied. SMS 201-995 had no significant effect on the number of colonic tumours induced. In the d...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.4.561
更新日期:1987-04-01 00:00:00
abstract::Chronic oral administration of the carcinogenic aminoazo dye N-methyl-4-aminoazobenzene (MAB) to rats is known to result in the induction of liver tumors. In order to assess the role of carcinogen-DNA adduct formation in MAB hepatocarcinogenesis, male rats were fed 0.06% [3'-3H]MAB in the diet for 1, 3 or 5 weeks. Gro...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.4.577
更新日期:1987-04-01 00:00:00
abstract::This report shows that generation of hydrogen peroxide (H2O2) by human polymorphonuclear leukocytes (PMNs) activated with tumor promoters of varying potency as first and second stage promoters correlates well with activities of these promoters in vivo. Those tested were 12-O-tetradecanoylphorbol-13-acetate (TPA), a co...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.3.455
更新日期:1987-03-01 00:00:00
abstract::A two-stage carcinogenesis experiment was performed in Syrian golden hamsters using a single intragastric initiation with 10 mg/kg body weight of 7,12-dimethylbenz[a]anthracene (DMBA) and repetitive topical promotion on the back skin with two different doses (80 and 160 mg, respectively) of benzoyl peroxide in 1 ml ac...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.3.479
更新日期:1987-03-01 00:00:00
abstract::In order to find potentially effective compounds that could prevent the covalent binding of the carcinogen N-hydroxy-2-acetylaminofluorene (N-OH-AAF) to rat liver macromolecules in vivo, the prevention of the covalent binding to RNA of the sulfate ester of the carcinogen N-OH-AAF by a series of thioethers was investig...
journal_title:Carcinogenesis
pub_type: 杂志文章
doi:10.1093/carcin/8.2.275
更新日期:1987-02-01 00:00:00